Vitamin K 1 -Injection
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Active Ingredients:
Each mL contains:
Phytonadione 10 mg
Polyoxyethylated fatty acid derivative 70 mg
Dextrose 37.5 mg
Water q.s.
Benzyl alcohol (added as a preservative) 0.9%
Indications:
Vitamin K1 injection is indicated in cattle, calves, horses, swine, sheep, goats, dogs and cats to counter hypoprothrombinemia induced by ingestion of courmarin based compounds, common ingredients in commercial rodenticides. Vitamin K1 injection is also indicated to counter hypoprothrombinemia caused by consumption of bishydroxycoumarin found in spoiled and moldy sweet clover.
Dosage and Administration:
Cattle, Calves, Horses, Swine, Sheep and Goats: Acute hypoprothrombinemia (with hemorrhage): 0.5-2.5 mg/kg of body weight, intravenously, at a rate not to exceed 10 mg/minute in mature animals and 5 mg/minute in newborn and very young animals. Nonacute hypoprothrombinemia: 0.5-2.5 mg/kg of body weight, intramuscularly or subcutaneously.
Dogs and Cats:
Acute hypoprothrombinemia (with hemorrhage): 0.25-2.5 mg/kg of body weight, intravenously, at a rate not to exceed 5 mg/minute. Nonacute hypoprothrombinemia: 0.25-2.5 mg/kg of body weight, intramuscularly or subcutaneously.
Intravenous Use:
Severe reactions, including fatalities, have occurred during and immediately after intravenous injections of phytonadione, even when precautions have been taken to dilute the Vitamin K1 and to avoid rapid infusion. Typically, these severe reactions have resembled hypersensitivity or anaphylaxis, including shock and cardiac and or respiratory arrest. Some animals have exhibited these severe reactions on receiving vitamin K1 injection for the first time. Therefore, the intravenous route should be restricted to those situations where other routes are not feasible and the serious risk involved is considered justified. Pain, swelling, and tenderness at the injection site may occur. The possibility of allergic sensitivity, including an anaphylactic reaction, should be kept in mind.
Precautions:
Protect from light. Store in a dark place
Cautions:
For animal use only. Not for human use. Keep out of the reach of children.
Presentation:
100 mL amber glass vials.
VEDCO - 11/10/98.1