GUAIFENESIN INJECTION
Click here for Current Product Data
Click here to enlarge photo.ACTIONS: Guaifenesin is a guaiacol derivative closely related to mephenesin. The propanediol derivatives are central-acting skeletal muscle relaxants which selectively depress transmission of nerve impulses at the internuncial neurons of the spinal cord, brainstem, and subcortical regions of the brain.
Propanediol derivatives have a wide margin of safety, the toxic dose is three times greater than the recommended dose. Respiration is not severely depressed, and the function of the diaphragm is uninterrupted. Tidal volume is slightly decreased and minute volume remains normal. In addition to skeletal muscle, the pharyngeal and laryngeal muscles are sufficiently relaxed for easier surgical intubation procedures. At the beginning of relaxation, there is a slight fall in blood pressure, however, throughout the relaxation period the heart function is unchanged. There is a slight increase in gastrointestinal activity. There is no apparent impairment of lung and kidney functions.
With the recommended administration and dosage of Guaifenesin Injection, induction is usually smooth and rapid (two to four minutes) providing a duration of action between 15 to 25 minutes. A slightly transient hemolysis occurs at a 5% concentration. Higher concentrations cause intravascular hemolysis.
The 5% dextrose minimizes the hemolytic action of Guaifenesin alone and reduces the tendency to form thrombi at the intravenous injection site. Guaifenesin appears safe when administered to pregnant mares and in human studies did not pass the placental barrier.
Metabolism and excretion of guaifenesin not well understood. Oxidation products are excreted in the urine as a glycuronimide.
If used for prolonged periods, such as in tetanus, serum hemoglobin levels should be monitored. Oxygen or sustained artificial respiration facilities should be available when the drug is employed. Additional care should be employed when administering the drug to anemic or hypovolemic animals with cardiac or respiratory problems.
Extreme care should be exercised at all times in handling this product to prevent the introduction of microbial contamination.
DOSAGE AND ADMINISTRATION For intravenous use only. Administer rapidly with a positive pressure system or gravity flow using a 12 to 14 gauge needle at the dose rate of 1 mL/pound of body weight. From a standing position the patient will begin to relax and gradually fall when approximately 1/2 the total dose has been given. Continue the remaining calculated dose for complete relaxation. Average duration of muscle relaxation is 10-25 minutes. For continued relaxation time, additional Guaifenesin Injection may be administered as determined by the veterinarian at a rate necessary to achieve the desired plane of relaxation. Recovery is usually smooth and uneventful with the horse regaining an upright position usually within 45 minutes after the medication is discontinued.
FOR INTRAVENOUS USE IN HORSES ONLY
Destroy partially used vials.
PRECAUTIONS: Avoid perivascular leakage to prevent local tissue irritation.
If used for prolonged periods, such as in tetanus, serum hemoglobin levels should be monitored. Oxygen or sustained artificial respiration facilities should be available when the drug is employed. Additional care should be employed when administering the drug to anemic or hypovolemic animals with cardiac or respiratory problems.
Extreme care should be exercised at all times in handling this product to prevent the introduction of microbial contamination.
DOSAGE AND ADMINISTRATION For intravenous use only. Administer rapidly with a positive pressure system or gravity flow using a 12 to 14 gauge needle at the dose rate of 1 mL/pound of body weight. From a standing position the patient will begin to relax and gradually fall when approximately 1/2 the total dose has been given. Continue the remaining calculated dose for complete relaxation. Average duration of muscle relaxation is 10-25 minutes. For continued relaxation time, additional Guaifenesin Injection may be administered as determined by the veterinarian at a rate necessary to achieve the desired plane of relaxation. Recovery is usually smooth and uneventful with the horse regaining an upright position usually within 45 minutes after the medication is discontinued.
FOR INTRAVENOUS USE IN HORSES ONLY
CAUTIONs: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
warnings:
& Packaging:
Material Safety Data Sheet
VEDCO GUAIFENESIN INJECTION
Address: 3915 S. 48Th Street Terrace
St. Joseph MO 64503
Emergency Telephone Number: 816-364-3777 or 816-253-9341
Trade name and synonyms: Guaifenesin Injection
Chemical name and synonyms: Guaifenesin Injection
Chemical Family: Veterinary Expectorant
Formula: N/A
Vapor Pressure (mm Hg): N/A
Vapor density (air=1):N/A
Solubility in water: Miscible
Appearance and odor: Clear, Practically colorless solution with characteristic odor of Guaifenesin
Specific Gravity(h20=1): 1.1
Percent volatile by volume(%) N/A
Evaporation rate: N/A
Flammable Limits: N/A
Extinguishing media: As appropriate for surrounding material
Unusual fire and explosion hazards: None
Special Fire Fighting Procedures: None
Effects of overexposure Nausea, vomiting, shortness of breath
Emergency First Aid Procedures Contact nearest poison control center.
Eyes: Flush eyes with water for 15 minutes. Seek medical attention if irritation persists.
Skin: Wash with soap and water. Seek medical attention if irritation persists.
Inhalation: Remove victim to fresh air. Apply artificial respiration if needed.
Ingestion: Induce vomiting if victim is conscious. (Never induce vomiting in an unconscious person). Seek medical attention if adverse reactions occur.
Incompatibility( materials to avoid): None
Hazardous Decomposition Products: None
Hazardous polymerization: Will occur ( )will not occur(xx)
Conditions to avoid: N/A
Waste disposal method: As per local, state and federal regulations.
Ventilation: None normally required.
Protective gloves: If desired.
Eye Protection: Safety goggles.
Other protective equipment: Special protective equipment not normally needed.